The Current Concept for Stem Cell Therapy in Spinal Cord Injury
- Authors: Alvaro Dowling1, Marcelo Molina2
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View Affiliations Hide AffiliationsAffiliations: 1 Orthopaedic Spine Surgeon, Director of Endoscopic Spine Clinic, Santiago, Chile 2 Department of Orthopaedic Surgery, Faculdade de Medicina de Ribeirão Preto USP (School of Medicine of Ribeirão Preto - University of São Paulo), Ribeirão Preto, SP, Brazil
- Source: Regenerative Medicine & Peripheral Nerve Endoscopy , pp 110-142
- Publication Date: August 2024
- Language: English
The Current Concept for Stem Cell Therapy in Spinal Cord Injury, Page 1 of 1
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Spinal cord injury with neurological deficits is devastating to patients and their families. After the immediate treatment that may involve spinal decompression and stabilization surgeries, patients are typically left with long-term disability. Intense research has focused on spinal cord regeneration, tissue repair, and reinnervation to improve function. Stem cell-based therapies are at the center of this effort. This chapter summarizes common spinal cord injury (SCI) patterns, including complete and incomplete SCIs, and their classification-based prognosis and treatments. They review the types of stem cells used in preclinical and clinical trials in the treatment of SCI and the associated ethical concerns and summarize the current state of the art of stem cellbased SCI treatments.
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