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- Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies: Volume 6
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Synthetic Analogues of Curcumin: The Search for Anticancer and Antioxidant Activities
- Authors: Vishnu Nayak Badavath1, Siddhartha Maji2, Munusamy Saravanabhavan3, Saurabh Gupta4, M.V.N.L. Chaitanya5, Venkatesan Jayaprakash6
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Pharmaceutical Chemistry, School of Pharmacy & Technology Management Studies, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Hyderabad 509301, India 2 Department of Chemistry, Oklahoma State University, Stillwater-74078, Oklahoma, USA 3 Department of Chemistry, KPR Institute of Engineering and Technology, Coimbatore, Tamil Nadu 641407, India 4 Department of Pharmaceutical Chemistry, School of Pharmacy & Technology Management Studies, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Hyderabad-509301, India 5 Department of Pharmaceutical Chemistry, School of Pharmacy & Technology Management Studies, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Hyderabad-509301, India 6 Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India
- Source: Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies: Volume 6 , pp 147-176
- Publication Date: August 2024
- Language: English
Synthetic Analogues of Curcumin: The Search for Anticancer and Antioxidant Activities, Page 1 of 1
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Curcumin, a key component of Curcuma longa L.'s rhizome, has a wide range of biological activities, as evidenced by intensive research over the last five decades. Curcumin has recently been utilized as an alternative medical ingredient in Southeast Asia to cure a variety of diseases, including stomach trouble, flatulence, jaundice, arthritis, sprains, wounds, skin infections, etc. Curcumin has also been shown to have antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer properties. Medicinal chemists employ rational structural modifications to improve the pharmacokinetic properties of a potential candidate to make them a therapeutically useful candidate. The objective of the chapter is to summarise the various modifications that have been carried out in curcumin's structural framework concerning its medicinal property. An elaborate discussion will be presented on antioxidant and anticancer activities.
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