Recent Trends of Chromene Syntheses
- Authors: Samarpita Das1, Pulkit Asati2, Harish K. Indurthi3, Ashutosh Kumar Dash4, Deepak K. Sharma5
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, U.P., India 2 Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi-221005, U.P., India 3 Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi-221005, U.P., India 4 Department of Medicinal Chemistry, Devsynthesis India Pvt. Ltd., Hyderabad, India 5 Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi-221005, U.P., India
- Source: The Role of Chromenes in Drug Discovery and Development , pp 17-42
- Publication Date: August 2023
- Language: English
Recent Trends of Chromene Syntheses, Page 1 of 1
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2H/4H-chromenes (2H/4H-Ch) structural scaffolds have been widely employed in the synthesis of many natural products and medicinal agents. 2H/4H-Ch have attracted considerable attention due to their various pharmacological activities, such as anticonvulsant, anticholinesterase, anticancer, anti-tuberculosis, antimicrobial, and inhibitory activity against monoamine oxidase (MAO), and anti-diabetic activities. In literature, the synthesis of 4H-chromenes was performed by one-pot Knoevenagel condensation of resorcinol, aryl aldehydes, and malononitrile in the presence of basic catalysts. Also, 2H-Ch analogs were performed by the Wittig-Horner-Emmons and Suzuki-Miyaura cross-coupling reactions. A description of recent advances in the syntheses of chromenes is presented in this chapter. The strategies for the synthesis of 2H/4H-Ch discussed in this chapter are organocatalysts, organometallic or metal catalysts, heterogeneous base catalysts, enzymatic catalysts, and green chemistry-based approaches. <br>
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