Phytochemical-Assisted Gold Nanoparticles for Burn Wound Management

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Wound healing is a complex multifunctional physiological process that mediates the contraction and closing of the wound area, which repairs the function of the skin barrier. Repairing of damaged tissue takes place as a sequence of processes in different cell types, including inflammation, proliferation and migration. The wound healing process can be mediated by natural products that possess anti-inflammatory, antimicrobial, pro-collagen synthesis, immunomodulatory, and cell-stimulating properties, which contribute to the accelerated healing process. Plants are an abundant source of biologically active compounds or a mixture of compounds with synergistic or additive effects as wound healing agents; therefore, their applications are limited when used as a single compound. However, nanotechnology is a promising powerful tool in the delivery of such drugs owing to their stability, high loading capacity and targeted delivery. This chapter aims to review the phytochemical-assisted gold nanoparticles for burn wound management. It is focused on synthesis, medicinal plants-based applications, and mechanism of action in wound healing. Also, it highlights the literature reports available on various in vitro and in vivo studies concerning the use of plant-based gold nanoparticles for wound healing. Pharmaceutical nanotechnology is an innovation used for regenerative medicine with potential use in the near future since it has proved efficient in managing burn wounds.