Efficient Synthetic Protocol and Mechanistic Study of Quinazoline Analogues and their Biological Importance
- Authors: Sumit Kumar Panja1, Satyen Saha2
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India 2 Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India
- Source: Advances in Organic Synthesis: Volume 9 , pp 121-146
- Publication Date: July 2018
- Language: English
Efficient Synthetic Protocol and Mechanistic Study of Quinazoline Analogues and their Biological Importance, Page 1 of 1
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Our main focus is on the recent developments for the synthesis of highly functionalized quinazoline derivatives in terms of an efficient, one-pot, eco-friendly, solvent-free, high yield, cost-effective, multicomponent strategy with the variation of substrates and catalytic conditions. Further, we have also emphasized on the mechanistic studies depending upon variation of substrates. Detailed mechanistic aspects have been established based on isolated intermediates and their single crystal X-ray structures. The biological importance of selected small quinazoline derivatives has been highlighted as well. In particular, we have observed that selected quinazolinebased small molecules show global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. Therefore, quinazolines can be used as scaffolds to design activator of miRNA expression, thus paving the way for the development of novel anti-cancer drugs.
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