Bentham Science Publishers

The knowledge of plant responses to various abiotic stresses is crucial to understand their underlying mechanisms as well as the methods to develop new varieties of crops, which are better suited to the environment they are grown in. Environmental Stress Physiology of Plants and Crop Productivity provides readers a timely update on the knowledge about plant responses to a variety of stresses such as salinity, temperature, drought, oxidative stress and mineral deficiencies. Chapters focus on biochemical mechanisms identified in plants crucial to adapting to specific abiotic stressors along with the methods of improving plant tolerance. The book also sheds light on plant secondary metabolites such as phenylpropanoids and plant growth regulators in ameliorating the stressful conditions in plants. Additional chapters present an overview of applications of genomics, proteomics and metabolomics (including CRISPR/CAS techniques) to develop abiotic stress tolerant crops. The editors have also provided detailed references for extended reading to support the information in the book.

Environmental Stress Physiology of Plants and Crop Productivity is an informative reference for scholars and researchers working in the field of botany, agriculture, crop science and physiology, soil science, and environmental sciences.

Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes. This knowledge has allowed researchers to understand, in a better way, the normal functioning of the cell process, which is used as a reference point for learning about and preventing or correcting pathologies that cause diseases.

This enzymology reference is a thorough compendium about reaction mechanisms occurring between the major enzymes related to the biosynthetic pathways of 3 important types of biological compounds – 6-carbon carbohydrates, fatty acids and amino acids – and their substrates, cofactors and residues. Readers will gain an understanding of the interaction between substrates or ligands with specific amino acid residues in biosynthetic enzymes. This understanding builds a foundation for learning about the biochemistry of different inhibitors used in the treatment of several diseases such as cancer, infectious diseases, and metabolic syndrome alterations such as diabetes and obesity.

Enzymes covered in the book include aldolases, isomerases, kinases, mutases, synthases, dehydrogenases, reductases, transferases, hydrolases, lyases among others, all of which are wide spread in biochemical transformations.

This reference, with its insights on common biochemical enzymes serves as a handy guide for students, researchers and professionals involved academia or industry related to pharmaceutical development, healthcare, food chemistry and other disciplines.

This handbook covers some primary instruments-based techniques used in modern biological science and medical research programs. Key features of the book include introductory notes for each topic, a systematic presentation of relevant methods, and troubleshooting guides for practical settings.

Topics covered in part 2 include:

· Fourier transform mid-infrared (FT-MIR) spectroscopy

· High performance liquid chromatography (HPLC)

· Raman spectroscopy

· Circular dichroism (CD) spectroscopy

· Transmission electron microscopy (TEM)

· Scanning electron microscopy (SEM)

· SEM-EDX and its applications in plant science

This book is a simple, useful handbook for students and teachers involved in graduate courses in life sciences and medicine. Readers will learn about the basics of featured techniques, the relevant applications and the established protocols.

Evaluating the impact of Laws Regulating Illicit Drugs on Health and Society serves as an informative reference for social science researchers and policymakers on the science behind drug regulation. The book presents contributions from many leading researchers in drug law and policy evaluation. The 12 chapters highlight scientific evidence from a diverse range of international projects on evaluation of different illicit drug laws. Each contribution takes policies into account while also using methodological tools and relevant data sets. For a priori evaluation, the modern leximetric approach is applied to compare different drug laws. For posterior evaluation the analysis of social and health outcomes, using standard and new indicators are presented, discussed and applied. Next, the book covers the use of drug market estimation methods in policy research. Specific new indicators allowing the evaluation of interventions such as harm reduction and prevention are presented and analysed using international research data. The book concludes with a summary of the links of illegal drug market gains with corruption, and its consequences. Evaluating the impact of Laws Regulating Illicit Drugs on Health and Society gives readers a unique, evidence-based perspective on the relationship between drugs, laws, policy and socioeconomic conditions. Key Features 1. Features 12 contributions from international experts on drug legislation and social science 2. Demonstrates evidence-based evaluation of drug laws and policies 3. Highlights Leximetric and forecast methods applied to illicit drug laws with examples 4. Highlights the use of standard and new socioeconomic indicators to evaluate drug laws and policies 5. Informs readers about different policy approaches to drug regulation and their consequences 6. Summarizes the links of illegal drug markets with corruption 7. Provides detailed references for further reading

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment. Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development.

Key Features:

- Presents information about different techniques and strategies for the synthesis of organic compounds

- Covers a broad range of biologically active compounds

- Easy to read topical presentation

- Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry

- Wide range of bibliographic references for further reading and exercises presented,

Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.

This book offers in-depth reviews of different techniques and novel approaches of using blockchain and artificial intelligence in smart healthcare services. The volume brings 14 reviews and research articles written by academicians, researchers and industry professionals to give readers a current perspective of smart healthcare solutions for medical and public health services.

The book starts with examples of how blockchain can be applied in healthcare services such as the care of osteoporosis patients and security. Several chapters review AI models for disease detection including breast cancer, colon cancer and anemia. The authors have included model design and parameters for the benefit of professionals who want to implement specific algorithms. Furthermore, the book also includes chapters on IoT frameworks for smart healthcare systems, giving readers a primer on how to utilize the technology in this sector. Additional use cases for machine learning for gesture learning. COVID-19 management, and sentiment analysis.

Extremophiles: Diversity, Adaptation and Applications brings up-to-date knowledge about different types of extremophiles, the fascinating group of microorganisms that love to live in extreme environmental conditions. The book consists of fourteen chapters, of which, the first provides an overview of all the major types of extremophiles and the relationship with their respective extreme environments. The chapters following this introduction explain the diversity of prokaryotes based on environmental conditions, adaptation mechanisms, and industrial applications. The book concludes with a summary of the diverse biotechnological and industrial applications of extremophiles, emphasizing the importance of these microorganisms for human welfare. The book is intended as a primary textbook reference that enriches the knowledge base of scholars in the field of microbiology and biotechnology. It can also serve as a secondary reference for anyone who is interested in research on extremophiles. Key Features: - Covers all the major types of extremophiles, including hyperthermophiles, psychrophiles, halophiles, acidophiles, alkaliphiles, xerophiles, oligotrophs, chemolithotrophs, anaerobes and others - Provides a fundamental overview of the microbiology of extreme environments - Supplements fundamentals with information about industrial and scientific applications - Presents information in a simple structured format suitable for learners - Includes references for further reading

Reinventing Technological Innovations with Artificial Intelligence delves into the transformative impact of Augmented and Virtual Reality (AVR) technology across industries. The book explores the merging of real and digital worlds, paving the way for personalized experiences in areas such as tourism, marketing, education, and more. With the potential to redefine business practices and societal norms in the era of Industry 4.0, AVR technologies hold untapped potential beyond gaming and entertainment. This volume presents a comprehensive overview of the current landscape, challenges, and prospects of integrating AVR with Artificial Intelligence (AI) for innovation and sustainability in various domains. The book presents 11 edited chapters contributed by technology and innovation experts that explore applications of AI, AR and VR technologies in different sectors in both public and private sectors. The editors have included reviews of technologies that impact human resource management, corporate social responsibility, healthcare, supply chain and criminal investigation. The reviews also highlight the role of AI in sustainable agriculture and smart cities.

Key Features:

Unveils the role of AVR in transforming real surroundings into digitally enhanced personal experiences.

Explores AVR's applications beyond gaming in diverse sectors like marketing, construction, education, and more.

Discusses challenges such as technical limitations, high costs, and resistance to adopting AVR.

Addresses the need to enhance the reliability and effectiveness of AVR technologies in various industries.

Provides a comprehensive perspective on AI innovations, AR, and VR technologies with real-world examples.

The book is an informative reference for researchers, professionals, and experts in technology, innovation, who are interested in the convergence of Augmented and Virtual Reality with AI for practical applications in diverse industries.

This book presents a review of the transformative impact of fintech and blockchain technologies on the financial industry. The book aims to bridge the gap between technical jargon and practical understanding, making it accessible to a wide audience. It begins by introducing fundamental concepts and tracing the evolution of these technologies. Subsequent chapters explore specific applications such as digital payments, lending, and investment management. The final sections address regulatory challenges, security concerns, and the future outlook for fintech and blockchain.

Key features of the book include a I) clear and concise explanation of complex technical concepts, making them understandable for both industry professionals and general readers, ii) real-world case studies and examples to illustrate the practical applications of fintech and blockchain, iii) insights into the regulatory environment and potential risks associated with these technologies and iv) a forward-looking perspective on the future of finance,

Readers will understand the intricacies of blockchain, including its underlying technology, smart contracts, and potential use cases in the financial sector. It also helps readers to anticipate industry trends.

Foods for Special Dietary Regimens is an overview of alimentation for people with specific medical conditions. Each of the nine featured chapters describes a recommended diet with special reference to the lifestyle or disease conditions in a specific patient group. The book covers a diverse range of patient groups that have special nutritional requirements including the elderly, athletes, vegetarians, diabetics and phenylketonurics to name a few. Diets for individuals affected by specific diseases such as celiac disease, autism, dyslipidemia, and COVID-19 are also recommended. Readers will gain a broad perspective about special dietary regimens, including information about what works and what does not for different patient groups, and potential avenues of research in this area.

Key Features:

- 9 chapters organized into a simple reader-friendly format

- guidelines for patient groups on lifestyle

- information for patient groups based on different clinically relevant diseases (including COVID-19)

- information about general concepts and clinical research

- references for further reading

This book presents research focused on the design of fractal antennas using bio-inspired computing techniques. The authors present designs for fractal antennas having desirable features like size reduction characteristics, enhanced gain, and improved bandwidths. The research is summarized in six chapters which highlight the important issues related to fractal antenna design and the mentioned computing techniques. Chapters demonstrate several applied concepts and techniques used in the process such as Artificial Neural Networks (ANNs), Genetic Algorithms (GAs), Particle Swarm Optimization (PSO) and Bacterial Foraging Optimization (BFO). The work aims to provide cost-effective and efficient solutions to the demand for compact antennas due to the increasing demand for reduced sizes of components in modern wireless communication devices.

A key feature of the book includes an extensive literature survey to understand the concept of fractal antennas, their features, and design approaches. Another key feature is the systematic approach to antenna design. The book explains how the IE3D software is used to simulate various fractal antennas, and how the results can be used to select a design. This is followed by ANN model development and testing for optimization, and an exploration of ANN ensemble models for the design of fractal antennas.

The bio-inspired computing techniques based on GA, PSO, and BFO are developed to find the optimal design of the proposed fractal antennas for the desired applications. The performance comparison of the given computing techniques is also explained to demonstrate how to select the best algorithm for a given bio-inspired design. Finally, the book explains how to evaluate antenna designs.

This book is a valuable resource for students (from UG to PG levels) and research scholars undertaking learning modules or projects on microstrip and patch antenna design in communications or electronics engineering courses.

This reference explores the science of signaling mechanisms associated with diseases like endocrine, metabolic, and immune disorders which are linked to oxidative stress-mediated disease mechanisms. The common diseases in these categories include diabetes mellitus and arthritis and conditions defined by inflammation and autoimmunity. These diseases involve metabolic pathways mediated by reactive oxygen species or free radicals. The pathways are targets in the mechanism of drugs that aim to treat related disorders. The book covers key topics in free radical biology that help to understand the nature of the pathways and the pharmacology of the drugs that are designed to target them.

5 chapters elucidate the free radical biology of the diseases.

1. Role of free radical biology in diabetes mellitus

2. Role of GSK3 in the regulation of insulin release and glucose metabolism

3. Regulatory role of NRF2 in rheumatoid arthritis

4. Role of free radical biology in Alzheimer's disease

5. Regulatory role of immune cells mediated antibody on rheumatoid arthritis Key features:

- Elucidates the key biochemical and pharmacological mechanisms that are mediated by free radicals in common endocrine, metabolic and immune diseases

- Explains the activation of immunological factors (like RF and ACPA) that trigger inflammation and arthritis

- Covers the role of free radicals in Alzheimer's disease and new interventions that target mitochondrial mechanisms

- Systematically explains the molecular biology of free radicals with the help of schematic diagrams

- Includes references for further reading The accessible and structured text in this reference makes it a suitable resource for all biomedical scientists, faculty, and postgraduate students in academia and industry.

Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.

The tenth volume of this series features 4 reviews on the following topics:

-Pharmacotherapy of Posterior Segment Ocular Infections

-Discovery and Development of Antimalarial Drug-Resistance Reversal Agents

-Omics Technologies and Anti-Infective Drug Discovery

-Possible Cutaneous Adverse Effects of Anti-Infective Vaccinations

Frontiers in Clinical Drug Research – Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology.

The eighth volume of this series presents comprehensive reviews of interest to readers interested in the treatment of inflammatory diseases, new antiviral agents and strategies, specific antiprotozoal drugs that work against leishmania and helminths, and a study on potential agents against American foulbrood in honey bees. The 7 reviews included in this volume are:

- Monoclonal antibodies as therapeutic agents for inflammatory diseases

- Pharmacotherapy of emerging antiviral agents

- Antiviral activity of vitamin D and COVID-19: current understanding

- Anti-infectives to combat leishmaniasis

- Anthelmintic drug discovery: current situation and future perspectives

- Therapeutic targets for emerging Zika virus infection and vaccines in clinical trials

- Agro-industrial waste: new source of raw material for the control of American foulbrood in honey bees

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology.

Volume 10 of the series continues to present novel information about new and interesting approaches to treat common neurological disorders, with a focus on neurodegeneration and pain medicine. The volume presents 7 detailed reviews in total.

- Neurodegenerative disease: prevention and treatment through plant extracts therapy

- Emerging novel approaches and recent advances in Parkinson`s disease treatment and diagnosis

- Neurotrophic factors to combat neurodegeneration

- Neural bases of executive function in ADHD children as assessed using FNIRS

- Modulation of mesenchymal stem cells, glial cells and the immune system by oligodeoxynucleotides as a novel multi-target therapeutic approach against chronic pain

- Chronic pain: focus on anticonvulsants

- A review of the impact of testosterone on brain and aging-related decline in brain behavioural function

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in neurology and allied disciplines.

The twelfth volume of this series features these reviews:

Chapter 1: Recent Drugs Tested in Clinical Trials for Alzheimer's and Parkinson's Diseases Treatment: Current Approaches in Tracking New Drugs

Chapter 2: Neurobiology of Placebo: Interpreting Its Evolutionary Origin, Meaning, Mechanisms, Monitoring, and Implications in Therapeutics

Chapter 3: Role of Gut Microbiota in Neuroinflammation and Neurological Disorders

Chapter 4: The Role of Age in Pediatric Tumors of the Central Nervous System

Chapter 5: Drug Repurposing in CNS and Clinical Trials: Recent Achievements and Perspectives Focusing on Epilepsy and Related Comorbidities

Chapter 6: Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning .

Frontiers in Clinical Drug Research – Diabetes and Obesity is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research.

The seventh volume of this series features 6 reviews on diabetes related topics for both medical specialists and pharmacologists.

- Clinical and diagnostic implications of glycated albumin in diabetes mellitus.

- Development of novel therapeutic groups and bioactive compounds from herbs for diabetes management

- Aspartame as a sugar substitute

- Mental health, adherence, and self-management among children with diabetes

- Cardioprotective effects of new generation anti-diabetic and lipid-lowering agents

- Epidemiology, pathophysiology, and treatment of diabesity

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity.

The sixth volume of this series features these six different perspectives on the application of computational chemistry in rational drug design:

- Computer-aided molecular design in computational chemistry

- The role of ensemble conformational sampling using molecular docking and dynamics in drug discovery

- Molecular dynamics applied to discover antiviral agents

- Pharmacophore modeling approach in drug discovery against the tropical infectious disease malaria

- Advances in computational network pharmacology for Traditional Chinese Medicine (TCM) research

- Progress in electronic-structure based computational methods: from small molecules to large molecular systems of biological significance

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field.

Volume 11 of this series brings together reviews covering immunotherapy of sepsis, new antimalarials, and the medicinal use of onions for respiratory diseases, among other topics.

Topics included in this volume are:

- Heme-oxygenase and autophagy connected as a cytoprotective mechanism: potential therapeutic target

- Development of recombinant therapeutic proteins in animal cells: Challenges and solutions

- Artemisinin Analogues as a Novel Class of Antimalarial Agents: Recent Developments, Current Scenario and Future Perspectives

- The effects of Allium cepa and their derivatives on respiratory diseases and the possible mechanisms of these effects

- Immunotherapy of Sepsis

Frontiers in Medicinal Chemistry is a book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This book series is essential for any medicinal chemist who wishes to be updated on the latest and the most important advances in the field.

This is the tenth volume of the series. The extensive volume brings 11 reviews on a variety of topics including anti-cancer drug therapeutics, food chemistry, toxicology and drug development strategies.

The list of topics in this volume includes:

Isoxazole derivatives as potential pharmacophore for new drug development

Contemporary trends in drug repurposing: identifying new targets for existing drugs

Pharmaceutical potential of pyrimidines as antiviral agents

Drugs and phytochemicals targeting cancer

Harnessing the neurological properties of indian brain health booster brahmi Carcinogenicity of hexavalent chromium and its effects

Medicinal plants: a future of modern medical system

Shikonin, a naphthaquinone of commercial importance: its biosynthesis and prospect for use as drugs Fast foods: chemical composition and implications for health Implications of DNA-acting agents as anticarcinogenic potential in breast cancer therapeutics

Aloe vera - a medicinal plant as potential therapeutic agents for liver cancer

Frontiers in Natural Product Chemistry is a book series devoted to important advances in natural product chemistry. The series features volumes that cover all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series.

Volume 11 of the series brings together 5 reviews:

- Medicinal importance of turmeric (curcuma longa) and its natural products

- Novel natural compounds for hepatocellular carcinoma treatment

- Herbal drug substitution (abhava-pratinidhi dravya): a key to stopping economic adulteration of botanical ingredients

- Synthetic and natural agents as bacterial biofilm inhibitors

- Quercetin chemistry, structural modifications, SAR studies and therapeutic applications: an update