Bentham Science Publishers

This book provides a compressive overview of nanotechnology in modern drug discovery for students and researchers. The book starts with the fundamentals of nanotechnology followed by nanomaterials in pharmaceutical drug design, drug delivery applications, regulatory aspects, formulation and nanoparticle biotransformation. It provides a step by step guide through the drug development process while conveying information about the benefits of nanomaterials for therapy. The book concludes with perspective on the future of nanotechnology-based drug discovery, summarizing current knowledge on nanotherapeutics and translational medicine.

Key Features

- Explains the fundamentals of nanotechnology in drug discovery

- Includes up-to-date information on modern nanopharmaceutical manufacturing, nanomaterials, and nanoparticle-based drug therapy

- Practice questions for learners and a list of references for advanced readers for each chapter

Advances in technology have enabled medicinal chemists to discover and formulate several highly specific, biocompatible, and non-toxic therapeutic agents for clinical applications. Nanotechnology has achieved significant progress in the last few decades and is crucial in every field of science and technology. Nanotechnology-based pharmaceuticals offer multifaceted and alternative methodologies in comparison to the limitations of many conventional clinical therapies. Expertise in designing and developing nanoformulations has helped in targeted drug delivery. Recently, the use of innovative therapeutic agents, particularly in nanomedicine, has accounted for a significant portion of the global pharmaceutical market and is predicted to continue to grow rapidly in the near future.

Nanotherapeutic Strategies and New Pharmaceuticals is an accessible multi-part reference which informs the reader about several new techniques based on nanotechnology. The chapters explain relevant topics in detail. The book is designed to encourage and help undergraduate, graduate and post-graduate students in the field of nanotherapeutics, pharmaceuticals and bio-organic chemistry through the use of didactic language and simple illustrations.

Part 1 of this book set explains general advances in nanomedicine, followed by chapters covering the role of nanotherapeutics in hematology and cancer treatment, as well as specific types of nanomaterials based on different components (such as boron, graphene, silver and other metals). The book also features a chapter that summarizes the processes for designing nanoparticles tailored for specific targets. The book serves as a textbook for students in pharmacology and medical biochemistry, as well as a quick reference for researchers on bio-organic chemistry, as well as general readers interested in nanomedicine.

Hepatocellular carcinoma (HCC) is a leading cause of death globally. Conventional chemotherapeutic agents are unable to penetrate cancerous hepatocytes completely and are toxic to non cancerous cells and tissues. This toxicity significantly compromises the therapeutic outcome of conventional chemotherapeutic agents which is also reflected in the high mortality of the disease. Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes. Thus, nanotherapeutics have shown considerable potential and there is tremendous impetus for rapid translation from the pre-clinical to the clinical domain to significantly prolong the survival in HCC.

In Nanotherapeutics for the Treatment of Hepatocellular Carcinoma, authoritative experts of the field have explored the important aspects of nanotherapeutics against HCC. The book exhaustively, vividly and explicitly describes the molecular pathogenesis, diagnostic aspects and nanotherapy of HCC, while also highlighting the challenges of conventional therapy and the benefits of nanotherapeutics. Chapters of the book also cover recent investigations of nanotherapeutics against HCC, types of nanomedicines, recent patents, commercially available nanotherapeutics and a future perspective to give a comprehensive review of the topic to readers. In addition to these defining features, the book provides several references for further reading. The book is an ideal resource on HCC nanotherapeutics for medical and pharmacology postgraduate students, faculties, researchers, and biomedical scientists working on HCC and nanotherapy.

Natural Feed Additives Used in the Poultry Industry addresses recent information on the use of different natural feed additives in poultry nutrition. Chapters in the book focus on the growth, production, reproduction and health of poultry.

Key Features:

- 15 chapters contributed by more than 30 experts and scientists involved in animal and poultry nutrition, physiology, toxicology, pharmacology, and pathology

- Chapters highlight the significance of a variety of herbal plant extracts and derivatives, cold pressed and essential oils, fruits by-products, immunomodulators, organic acids, probiotics, nanoparticles and their role in poultry industry instead of the growth promoter antibiotics.

- Provides details about the use of antibiotic as growth promoters in poultry and the development of bacterial resistance.

- Provides a holistic approach on how natural feed additives can provide an efficient solution to animal health,

- Covers the main categories of poultry, including broiler chickens, laying hens, quails, geese, ducks, and turkey.

- References in each chapter for further reading

This handbook represents an up-to-date review of the existing knowledge on natural feed additives, both in vitro and in vivo and the basis for future research. The text is useful to students of poultry sciences, nutritionists, scientists, veterinarians, pharmacologists, poultry breeders, and animal husbandry extension workers.

New Avenues in Drug Discovery and Bioactive Natural Products is the second volume of the Natural Medicine book series. It is devoted to current research in drug discovery from natural sources. The volume features 13 chapters that cover modern analytical and scientific approaches. The book starts with chapters on advanced analytical and research techniques, such as genomic mining, quality control of herbal drugs, DNA fingerprinting, high-throughput screening, molecular docking and extraction techniques. The contributors provide a summary of challenges for researchers and commercial applications where possible. The book also features chapters dedicated to specific medicinal agents that target a disease (glycosides, SARS-CoV2 spike protein inhibitors, and andrographolides. The collection of important research topics in natural product chemistry aims to help the scholars and researchers in the scientific community that are involved in the extraction and development of new medicines.

Natural Products for Skin Diseases: A Treasure Trove for Dermatologic Therapy is an enlightening journey through the realm of natural remedies for various skin diseases. The editors have compiled information on effective and holistic treatment approaches that can be applied in clinical settings. This book brings diverse range of topics, including skin protection against harmful radiation, natural remedies for burns and wounds, management of skin pigmentation issues, and herbal treatments for scabies. It also explores the potential of natural cosmetics and their future applications, along with the use of natural products and nanoparticles in skin delivery. All chapters are contributed by experts in dermatology and herbal medicine, and are supplemented with scientific references for advanced readers. The book primarily serves as a textbook for students in medicine and dermatologists in training. It also serves as a valuable guide for dermatologists, researchers, and healthcare professionals, revealing the treasure trove of benefits that natural products offer for treating skin diseases.

Rheumatoid arthritis (RA) is the most common inflammatory complication and affects approximately 1 % of the global population. It affects three times more women than men. RA is an autoimmune disorder elicited by exposure of genetic factors from the host to unknown antigens causing arthritogenic complaints. It also includes the activation of lymphocytes as well as CD4+ helper T cells along with the local release of chronic inflammatory mediators and cytokines like tumor necrosis factor (TNF-α) and various cytokines like interleukins (IL) that enormously affect the joints. The available allopathic therapies for RA are not a cure for the complications, and antibody therapy and surgical procedures are expensive.

However, in the present era, researchers and healthcare professionals have moved toward natural medicines obtained from plants and other natural sources. Research-based on developments in phytomedicine has progressed steadily. Evidence has been collected to show the massive therapeutic potential of medicinal plants used in various traditional systems against many pathological complications. Researchers have focused on the therapeutic potential of natural products used for treatment and counteracting various disorders along with their complications having negligible adverse effects.

Natural Products for the Management of Arthritic Disorders compiles current knowledge about the bioactive compounds and herbal formulations useful in the treatment of rheumatoid arthritis. 11 chapters explain the role of natural products in the management of rheumatoid arthritis. Topics have been contributed by experts in medicinal chemistry and rheumatology.

The book first introduces the reader to rheumatoid arthritis before delving into conventional and alternative therapies for the disease. The editors have also included special topics such as the biomarkers for RA, cytokines and anti-inflammatory mediators, and preclinical and clinical studies. The range of topics should provide a comprehensive overview of natural remedies for arthritis and the role of natural products in anti-arthritic drug development.

The information will be useful for many readers including medical and pharmacology students, multidisciplinary research scholars, scientists, pharma/herbal/food industrialists, and policy makers.

In this handbook, the authors provide a practical, easily accessible guide of necropsy techniques for examining wildlife. Chapters introduce the reader to the value of necropsy in studying wildlife in general, sample collection methods, cadaveric phenomena and necropsy techniques for a variety of organisms ranging from invertebrates to mammals. The book addresses some of the peculiar characteristics of veterinary autopsy specific to different types of specimens. The goal of this book is to equip the reader with the information necessary to conduct a forensic examination in order to reach a conclusive diagnosis of an animal’s death, while also understanding it in an ecological context.

Necropsy Techniques for Examining Wildlife Samples is intended as an essential handbook for students and professionals of biology, zoology and veterinary medicine as well as professionals, who work in natural parks, wildlife rehabilitation centers and biological or zoological parks as conservationists, researchers or animal handlers.

This reference is the definitive guide to common neurodegenerative diseases that affect humans. The book covers mechanisms of some of the most well-known neurodegenerative diseases, their biomarkers, neuropharmacology, and emerging treatment strategies.

The book introduces the subject of neurodegeneration by outlining the biochemistry, pathophysiology and multifactorial neurological mechanisms (the role of genetics, environmental factors and mitochondrial damage, for example). Next, it explains some of the most studied diseases, namely, Parkinson's Disease, Alzheimer's Disease, Huntington's Disease, and Multiple Sclerosis. Subsequent chapters delve into current knowledge about diagnostic and immunological biomarkers, followed by a summary of novel therapeutic strategies.

Special attention has been given to the role of medicinal plants in attempting to treat neurodegenerative diseases, as well as the public health burden posed by these conditions.

Key Features - give readers an overview of multifactorial disease mechanisms in neurodegeneration

- covers some major neurodegenerative diseases in detail

- covers diagnostic and immunological biomarkers

- explores current therapeutic strategies and drug targets in common neurodegenerative diseases

- offers a simple presentation with references for advanced readers

The book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.

Increasingly global and online social interactions and financial transactions involve digital data, computing devices and the internet. With cloud computing, remote computing, enterprise mobility and e-commerce on the rise, network security has become a priority. Selecting an appropriate algorithm and policy is a challenge for computer security engineers, as new technologies provide malicious users with opportunities to intrude into computer networks.

New Age Cyber Threat Mitigation for Cloud Computing Networks provides cloud and network engineers answers to cybersecurity challenges. It highlights new options, methodologies and feasible solutions that can be implemented in cloud architecture and IT Infrastructure, thereby securing end users. Chapters cover many topics related to cyber threats in the modern era.

These topics include:

Ransomware and DDoS attacks

Security algorithms

Design and implementation solutions for resilient and fault-tolerant cloud and network services

Security policy

End user data security The book is an essential resource for anyone involved in cloud computing and network security, including learners, professionals and enthusiasts.