Bentham Science Publishers

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical basis of drug action. This first volume of the series is comprised of 8 chapters focusing on basic background information about medicinal chemistry. It takes a succinct and conceptual approach to introducing important fundamental concepts required for a clear understanding of various facets of pharmacotherapeutic agents, drug metabolism and important biosynthetic pathways that are relevant to drug action. Notable topics covered in this first volume include the scope and importance of medicinal chemistry in pharmacy education, a comprehensive discussion of the organic functional groups present in drugs, and information about four major types of biomolecules (proteins, carbohydrates, lipids, nucleic acids) and key heterocyclic ring systems. The concepts of acid-base chemistry and salt formation, and their applications to the drug action and design follow thereafter. These include concepts of solubility and lipid-water partition coefficient (LWPC), isosterism, stereochemical properties, mechanisms of drug action, drug receptor interactions critical for pharmacological responses of drugs, and much more. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body.

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting the Nervous System is the second volume of the series and it presents 8 chapters focusing on a comprehensive account of drugs affecting the nervous system. The volume informs readers about the medicinal chemistry of relevant drugs, which includes the mechanism of drug action, detail structure activity relationships and metabolism as well as clinical significance of drugs affecting autonomic and central nervous system. Chapters in this volume cover cholinergic drugs, adrenergic drugs, antipsychotics, antidepressants, sedatives, hypnotics, anxiolytics, antiepileptic drugs, anesthetics and antiparkinsonian drugs, respectively. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body. The information offered by the book chapters will give readers a strong neuropharmacology knowledge base required for a practicing pharmacist.

This comprehensive reference explores medicinal plants, phytomedicines, and traditional herbal remedies as potential sources for the prevention and treatment of COVID-19. It features 9 chapters authored and edited by renowned experts. The book specifically highlights the promising drug discovery opportunities grounded in bioactive compounds from medicinal plants and herbal medicines, offering insights into combatting SARS-CoV-2 infections and respiratory complications.

Key Highlights:

Drug Discovery Potential: Explores the vast potential of medicinal plants, phytomedicine, and traditional remedies against COVID-19, shedding light on groundbreaking drug discovery avenues.

Cutting-Edge Insights: Provides up-to-date insights into the use of medicinal plants, herbal drugs, and traditional medicines in the fight against COVID-19.

Natural Immune Boosters: Details the use of indigenous herbs, spices, functional foods, and herbal drugs for boosting immunity and preventing SARS-CoV-2 infections.

Drug Repurposing: Highlights innovative drug repurposing strategies using phytomedicine-derived bioactive compounds and phytochemical databases for COVID-19 drug development. Additional features of the book include a reader-friendly introduction to each topic and a list of references for advanced readers. This timely reference is an informative resource for a broad range of readers interested in strategies to control COVID-19, including postgraduate researchers, and pharmaceutical R&D experts. It also serves as a handbook for professionals in clinical and herbal medicine.

This book provides readers a fundamental understanding of the science and applications of medicinal and aromatic plant materials. Chapters of this handbook covers the basics of ethnobotany, (bio)active compounds and their natural sources. Information about the cosmetic, nutritional, medicinal and industrial uses (dyes, tannins and biocides) is also presented. Readers will also learn about concepts central to quality control processes, sustainable management, wild harvesting and the economic valuation of the industrial impact of endemic plants.

The volume also presents a case study of the wormwood (Artemisia absinthium L.), which is helpful in explaining the above concepts.

This book is intended as a handbook for undergraduate students and teaching professionals in research and higher education institutions involved in agricultural engineering, pharmacy, forestry, natural product chemistry. Non experts interested in aromatic and medicinal plant agriculture, transformation and commercialization will also find the content informative.

Medicinal and Environmental Chemistry: Experimental Advances and Simulations is a collection of topics that highlight the use of pharmaceutical chemistry to assess the environment or make drug design and chemical testing more environment friendly.

The eleven chapters included in the second part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. This part is more specialized in nature, focusing primarily on the effects of air pollution and water contamination on human health. Chapters covering pharmaceutical interventions and pollution control measures, respectively follow these initial topics.

Part II also features specialized topics that aim to address some unique challenges of the above mentioned problems including antibiotic pollution, pharmaceutical analysis of pollutants, chemosensors, biosteric modifications and new drug development strategies against SARS-CoV2.

Key Features:

1. 11 topics which blend environmental chemistry and medicinal chemistry

2. Contributions from more than 40 experts

3. Includes topics covering effects of air pollution on human health and disease

4. Includes specialized topics on pharmaceutical analysis in the environment, and modifications of compounds for pharmaceutical purposes

5. Bibliographic references

This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

Melanin is a biological molecule associated with pigmentation in humans and animals. However, melanin has been observed to have other functions such as neuroprotection and energy production. In Melanin, the Master Molecule, researchers summarize several decades worth of knowledge on melanin and its physicochemical properties. Nine chapters explain the intrinsic biochemistry of melanin, comparisons with conventional energy producing and respiratory biomolecules, the property of melanin to transform light energy into chemical energy through the dissociation of the water molecule, and the theories of melanin based energy production in the nervous system, the cell nucleus, muscles and the eye, and the role the role of melanin in the context of ageing. The authors also delve into the possibility of melanin being the key molecule needed to spark life since its water dissociating property through the absorption of light energy emulates the role of chlorophyll, but unlike the latter, it is not limited to the plant cell environment. Hence, melanin is referred to as the master molecule which can provide a missing link to the biochemical processes behind the origin of life.

Melanin, the Master Molecule is an exciting reference for biochemists and laymen interested in the science of melanin and a new perspective on the origin of life as we know it.

Ukot's Back to Basics MCQs (Volume 3) expands the trusted series with a comprehensive collection of multiple-choice questions that sharpen clinical reasoning and reinforce essential concepts across three vital domains of medical practice: Mental Health, General Pediatrics, and Family Medicine.

Designed for medical students, postgraduate trainees, and practicing clinicians, this volume combines exam-focused preparation with real-world applicability. The carefully structured chapters not only test knowledge but also strengthen diagnostic accuracy, therapeutic decision-making, and holistic patient management skills.

Key Features

Covers critical areas of psychiatry including anxiety, mood disorders, schizophrenia, substance use, psychotherapies, and geriatric psychiatry.

Explores pediatric essentials from neonatal care and congenital conditions to malnutrition, infections, tumors, and cardiac disorders.

Integrates principles of family medicine such as holistic care, ethics, genomics, health promotion, preventive strategies, and clinical audit.

Strengthens exam readiness with detailed answers, explanatory notes, and differential diagnoses.

Contains comprehensive index and bibliography for further study and clinical practice.

This monograph provides a current and in-depth review of scholarly information about mesenchymal stem cells and their application in the craniofacial region of the human body. Chapters in this volume cover biological and conceptual information about mesenchymal stem cells, induced pluripotent stem cells, craniofacial regeneration, new methods of scaffold fabrication, tooth regeneration and three-dimensional printing in dentistry. The book is suitable for clinicians and cell biologists aiming to gain a better understanding of the promising field of craniofacial regenerative medicine.

The book focuses on a new interdisciplinary understanding of the metabolic syndrome (MetS) for better health maintenance. It provides an updated understanding of the underlying principles, possible targets, implementation approaches and the effectiveness of various avoidance strategies in MetS. The chapters cover a wide range of topics, including major advances in general aspects of metabolic syndrome, functional changes, new diagnostic methods, genotype-phenotype associations, the effect of exercise and multitarget pharmacotherapeutic strategies for MetS and perspectives on personalized medicine. It also discusses epigenetic mechanisms underlying MetS-related processes and epigenetic strategies to prevent related diseases. The book also presents summarized information about the associated factors and mechanisms linking cancer and MetS and to identify potential targets for the treatment of these patients. A better understanding of the various linkages will provide greater insight into the management of cancer patients by preventing MetS and related alterations.

Key Features

- Comprehensive information focused on the biological factors and physiological changes associated with metabolic syndrome

- Updates on metabolic syndrome diagnosis and management

- Summarized information on clinical implications for cancer therapy

- Thoroughly referenced chapters with summaries and discussions for quick understanding

The book is an informative resource for interdisciplinary scientists and researchers in life sciences and medicine. Furthermore, it, including the insulin-like growth factor (IGF-1) pathway, estrogen signaling, visceral adiposity, hyperinsulinemia, hyperglycemia, aromatase activity, adipokinase production, angiogenesis, oxidative stress, DNA damage and pro-inflammatory cytokines, and their clinical implications in cancer therapy.

The aim of this Ebook is to provide a comprehensive overview of the basic production techniques for manufacturing of metal-based graded materials. A concise description of experimental methods and short analysis of some specific structures obtained are presented. In order to provide an easy-readable text, general mathematical models and specific tools for management of graded structures in metal matrix composites are presented separately in appendices. The movement of solid particles (reinforce phase) in gravity and centrifugal casting are widely discussed. Basic equations, which describe solid particle movement in case of Lorenz force application at graded structure production techniques and comprehensive model of physical phenomena in gasar technology, can also be found in this Ebook. The Ebook is useful for colleagues, who work in the field of graded structures and materials, and who need compact informative view of recent experimental and theoretical approaches in this area.

This book provides a comprehensive overview of metal matrix composite manufacturing, including fabrication methods, characterization techniques, and manufacturing applications. 10 chapters cover fundamental and applied topics on matrix metal composites. The book is a resource for all readers seeking to gain an in-depth understanding of metal matrix composites with its relevance to the modern industry.

Key Features

- Includes fully referenced contributions by experts in materials science

- Provides an introduction to the subject, and a future prospective for a broad range of readers

- Reviews current knowledge on fabrication techniques and structure property relationships of metal matrix composites

- Includes dedicated chapters for reinforced composites (carbon fiber, carbon nanotubes, aluminium)

- Includes guidance on material wear and tear and

- Provides an investigation for process optimization for EDM for newly developed composites

It is designed to be an essential resource for students and professionals in the field of materials science and engineering, as well as researchers and engineers working on metal matrix composite in manufacturing industries.

Metallurgy and Technology of Steel Castings is a comprehensive textbook for students and professional engineers in the field of foundry engineering and materials science. The topics covered in this book explain the association between the quality of liquid metal and the properties of the finished cast. Readers will learn about the thermodynamic conditions for addition and recovery of chemical elements (such as Cr, Ni and Mo) in steel, degasifying processes, the influence of alloying additives for manufacturing steel castings that operate in extreme temperatures, anti-corrosive steels and basic cast conditions for making the castings (pouring and heat treatment systems).

Metallurgy and Technology of Steel Castings gives readers essential information about steel and steel cast manufacturing processes and equips them with the knowledge to overcome the challenges faced in the foundry environment.

Methods and Techniques in Nematology discovers the intricate world of nematodes, a comprehensive guide essential for researchers, academics, and enthusiasts alike. This book addresses the methods crucial for studying these unsegmented roundworms, covering everything from sampling techniques to advanced molecular diagnostics and biodiversity analysis.

Key Features:

- Detailed sampling methods for diverse habitats.

- Extraction procedures for soil, root, and entomopathogenic nematodes.

- Microscopic observation techniques including SEM and DIC.

- Molecular diagnostic tools such as PCR and RFLP.

- Introduction to bioinformatics for nematology.

- Comprehensive biodiversity analysis, both conventional and molecular.

- Culturing and greenhouse studies for experimental purposes.

Recent advances in science and technology such as online monitoring techniques, coupling of various processing methods, surface characterization and measurement techniques have greatly promoted the development of ultraprecise machining technology. This precision now falls into the micrometer and nanometer range - hence the name micro & nanomachining technology (MNT).

Machining is a complex phenomenon associated with a variety of different mechanical, physical, and chemical processes.

Common principles defining control mechanisms such as O Jamie de geometry, Newton mechanics, Macroscopic Thermodynamics and Electromagnetics are not applicable to phenomena occurring at the nanometer scale whereas quantum effects, wave characteristics and the microscopic fluctuation become the dominant factors. A remarkable enhancement in computational capability through advanced computer hardware and high performance computation techniques (parallel computation) has enabled researchers to employ large scale parallel numerical simulations to investigate micro & nanomachining technologies and gain insights into related processes.

Micro and Nanomachining Technology - Size, Model and Complex Mechanism introduces readers to the basics of micro & nanomachining (MNT) technology and covers some of the above techniques including molecular dynamics and finite element simulations, as well as complexity property and multiscale MNT methods.

This book meets the growing need of Masters students or Ph.D. students studying nanotechnology, mechanical engineering or materials engineering, allowing them to understand the design and process issues associated with precision machine tools and the fabrication of precision components.

Microalgae could play an important role in the achievement of sustainability goals related to the generation of renewable energy and greenhouse gas (GHG) emissions. These photosynthetic microorganisms are able to capture CO2 and, therefore, can be used to produce biofuels such as ethanol, methane and green diesel. Other factors, such as their high growth rate, ability to use wastewater as a culture medium and the ability to grow on non-arable land makes them a potentially economical source of biofuel production on a large scale.

This monograph introduces the reader to the basic and applied science of microalgal biofuel production. Chapters in the volume give information about bioethanol and biogas production from microalgal sources, the fermentation process, optimization of culture parameters and industrial applications of biomass projects.

The book is a useful reference for biotechnology and environmental science graduates and professionals interested in biofuel production.

Global plastic production is estimated to be over 300Mt annually. Most conventional plastics are predominantly produced from fossil fuels and are highly resistant to biodegradation, and only a small share of about 20% of spent plastics is believed to be recycled, which is a cause for environmental concern. Biodegradable plastics would solve this concern as they are a sustainable alternative, yet these do not even cover 5% of the global plastic market.

Microbial polyhydroxyalkanoates (PHAs) are a versatile group of polyesters produced by nature as prokaryotic storage materials. PHAs can be produced through sustainable bioprocess engineering and have displayed remarkable flexibility in their physical and chemical properties. PHAs are the subject of several scientific papers and numerous PHA patents have also been filed, generating significant interest in the plastic production industry.

To develop overall sustainable and efficient production processes, all bioprocess steps need to be thoroughly understood and accounted for. These processes start with the selection of suitable inexpensive raw materials (microbes and enzymes), optimizing the process engineering and process regime, and conclude with the enhancement of product recovery in terms of time, energy, and material input.

Microbial Biopolyester Production, Performance and Processing: Bioengineering, Characterization, and Sustainability is a compilation of eight chapters covering bacterial polyesters, green plastics and PHAs from various angles. The contents of this volume focus on sustainable practices focus on the sustainability of processes that involve the synthesis and recycling of these meterials. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production.

Microbial Insights into Wastewater Treatment and Environmental Sustainability examines the way microorganisms are reshaping the way we tackle environmental challenges, offering practical and science-driven strategies for wastewater remediation, pollution control, and resource recovery. Integrating microbiology, environmental science, and biotechnology, this volume reveals how microbial processes underpin sustainable solutions for ecosystem restoration and global environmental health.

The book begins with foundational concepts, such as the microbial ecology of polluted sites and mechanisms of pollutant sequestration, to specialized topics including arsenic bioremediation, microbe-driven green nanotechnology, and biocontrol innovations. It further investigates plant-microbe partnerships that enhance environmental resilience, and explores cutting-edge molecular and biosensing techniques for real-time environmental monitoring. Case studies highlight the transition from laboratory research to field-scale applications, while forward-looking sections consider microbial nanotechnology for sustainable energy generation and microbial strategies for waste valorization.

Key Features:

Explains microbial roles in pollution mitigation and environmental recovery

Demonstrates sequestration, bioremediation, and nanotechnology-based microbial innovations

Integrates molecular tools and biosensors for environmental health assessment

Applies microbial strategies to wastewater treatment, energy production, and waste management

Highlights real-world case studies linking theory to practice

Incorporates multidisciplinary insights from global research contributors

Advances sustainable development through microbial resource recovery.

Microbiology for ICAR NET: A Comprehensive Exam Preparation Guide is a valuable resource tailored for students preparing for the ICAR NET exam in Microbiology. This guide offers an in-depth overview of key microbiological topics, including microbial physiology, soil microbiology, environmental microbiology, and microbial biotechnology. Organized into eight comprehensive chapters, the book covers foundational concepts such as the scope of microbiology, prokaryotes, and microscopy, while aligning closely with the ICAR NET syllabus.

Ideal for ICAR NET aspirants, this guide also serves as a solid review tool for microbiology students, researchers, and professionals.

Key Features:

- Includes multiple-choice, true/false, and fill-in-the-blank questions for active learning.

- Detailed answer key for self-assessment and concept reinforcement.

- Comprehensive coverage of topics essential for ICAR NET Microbiology exam preparation.

- Covers a wide range of microbiology topics.

Micronutrient Deficiency in Soils and Plants highlights the problems caused by micronutrient deficiencies in vegetative production. This eBook emphasizes on the necessary requirements for plant growth micronutrients, the vital deficiency symptoms of micronutrients and their crucial role in plant metabolism.

The scope of this eBook covers a range of topics including micronutrient deficiency, the availability of micronutrient in soils, plant metabolism and micronutrient solubility.

The contents of this eBook include chapters on micronutrient solubility and availability in soils, the role of micronutrients in plant metabolism and growth and diagnostic tools to assess deficiencies of iron, zinc, copper and other micro-nutrients.

Micronutrient Deficiency in Soils and Plants is a valuable resource for MSc and PhD students, academic personnel and researchers seeking updated and critically important information on major nutritional problems in agricultural soils and crops.

Microplastic Pollution: Causes, Effects, and Control sheds light on the causes, effects, and control of microplastic pollution, providing valuable insights into the tools and techniques for analysis, the impact on ecosystems, and the potential risks to human well-being. The editors focus on the urgency of addressing this global environmental challenge through collaborative efforts and sustainable solutions. This reference features 10 edited chapters covering multiple aspects of microplastic pollution. The book introduces the reader to various tools and techniques used to analyze microplastic pollution in both aquatic and terrestrial ecosystems. It then examines the sources, pathways, and levels of microplastic contamination in the environment and explains how to evaluate the potential health risks for the nearby communities. The impact of microplastic on flora and fauna is presented in one chapter. To emphasize the importance of assessing microplastic contamination, the editors present a case study conducted in Thoothukudi, South India, to explore the implications of microplastic pollution on human health. The book also provides information on solutions to microplastic pollution including the use of bioplastics and removal techniques. Microplastic Pollution: Causes, Effects, and Control equips readers with a complete understanding of the global challenge of microplastics, fostering awareness and encouraging further research and action to protect our ecosystems and human health from their detrimental impact. It is an ideal handbook for environmental science researchers and students who need to understand microplastic pollution and plan environmental impact assessments for academic research and professional projects.

Key Features

- Comprehensive coverage of microplastic pollution with 10 structured chapters

- Informs readers about important parameters to understand and measure the impact of microplastics on local fauna, flora and the surrounding environment

- Covers evaluation and remediation of microplastics in both terrestrial and marine environments

- Includes references for advanced readers

- Includes a case study on the effect of microplastics in Thoothukudi, South India

This volume presents information about protocols for micropropagation of more than 40 species of medicinal plants. The contents combine knowledge about the scientific principles of micropropagation with state of the art updates in tissue culture techniques presented by plant scientists.

The readers will learn about techniques required to grow plants in challenging conditions that aim to reduce the impacts of injudicious harvesting, deforestation, climate change, pollution, urbanization and other factors that limit the ability to meet current demand. General topics such as biotization and pharmaceutical investigation are also included to guide readers about the significance of these plants in research and development for new medicines.

The book provides protocols for micropropagation of important medicinal plants like Rauvolfia serpentina, Catharanthus roseus, Withania somnifera, Tylophora indica, Bacopa monnieri, Aloe vera, Phyllanthus amarus, Allium sativum, Moringa oleifera, Operculina turpethum, Glycyrrhiza glabra, Pterocarpus marsupium, Vetiver grass, Ruta graveolens, Tinospora cordifolia, Kaempferia, Hedychium, Decalepis hamiltonii, Saraca asoca, Wrightia tinctoria, Wrightia arborea, Artemisia absinthium, Aegle marmelos, Atropa acuminata, Atropa belladonna, Alpinia species, Hedychium species, and Cissus species.

This book is a handy reference for medicinal chemists, horticulturists and pharmacists who want to learn about the growth and conservation of important medicinal herbs and plants.

Mind Maps in Biochemistry presents a series of concept and knowledge maps about biochemical compounds, systems and techniques. The book illustrates the relationships between commonly used terms in the subject to convey the meaning of ideas and concepts that facilitate a basic understanding about the subject for readers.

Chapters of the book cover both basic topics (lipids, carbohydrates, proteins, nucleotides, enzymes, metabolic pathways, nutrition and physiology) as well as applied topics (clinical diagnosis, diseases, genetic engineering and molecular biology).

Key Features

i. Topic-based presentation over 16 chapters

ii. Coverage of basic and applied knowledge

iii. Detailed tables, flow diagrams and illustrations with functional information about metabolic pathways and related concepts

iv. Essay and multiple-choice questions with solutions

v. Exercises for students to construct their own mind maps, designed to improve analytical skills

Mind Maps in Biochemistry is an ideal textbook for quick and easy learning for high school and college level students studying biochemistry as well as teachers instructing courses at these levels.

Mind Maps in Clinical Chemistry presents information about clinical laboratory techniques with the for junior healthcare professionals, medical residents and students. Book chapters provide guides which enable readers to suggest, arrange and interpret clinical chemistry tests effectively to enhance clinical care.

Chapters of the book cover range of topics relevant to laboratory testing, clinical physiology and medical biochemistry which will equip readers with adequate knowledge on the subject.

Key Features

i. Topic-based presentation over 24 chapters

ii. Coverage of practical and theoretical knowledge

iii. Lucid and integrated presentation of concepts

iv. Wide range of topics covered including laboratory testing, clinical physiology of organs and systems as well as endocrinology and toxicology

v. packed with practical lab testing information

Mind Maps in Clinical Chemistry is an ideal textbook for quick and easy learning of clinical laboratory knowledge for undergraduate and graduate students as well as teachers instructing courses at these levels.

Historically, patients with advanced structural heart disease have required major surgery to correct the defect. This includes, for example, patients with atrial septal defect, aortic valve disease and mitral valve disease. In recent years there have been major advances in the treatment of patients with structural heart disease using minimally invasive, percutaneous treatments. This field continues to evolve quite quickly.

This e-book outlines the current situation with respect to minimally invasive treatment of a wide range of structural cardiac defects. Each chapter covers details of a structural defect and outlines various technologies available for treating the condition. Indications for procedures as well as details of the procedures are also provided wherever possible. This e-book should be a useful reference for readers interested in minimally invasive cardiovascular surgery.

Osteosarcoma is a rare bone tumor that has a high incidence among children and young adults. Despite recent therapeutic developments, osteosarcoma still presents major hurdles to achieving successful results, mainly due to the presence of multi-drug-resistant cells.

This monograph primarily aims to provide information about the basic science behind the treatment of osteosarcoma along with experimental results for a novel formulation that overcomes multidrug resistance, and therefore, may serve as a viable treatment option. The book starts with an updated and concise guide to the pathophysiology of the disease, while also introducing the reader to new therapies and materials (specifically chitosan, polyethyleneimine, poloxamers, poloxamines, and Pluronics ) used in the treatment process along with the aims of the experiments present subsequently. Next, the book documents the materials and methods used in developing polymeric micelles for delivering drugs to osteosarcoma sites. By explaining the basics of nanomedicine as a starting point, readers will understand how polymeric micelles act as facilitators of drug transport to cancer cells, and how one can synthesize a small stable micelle (by creating derivatives of base nanomaterials), capable of actively targeting osteosarcoma cells and overcoming multi-drug resistance. The chapter explains the synthesis and characterization techniques of the materials used to develop polymeric micelles.

The results, a reflection of the conjugation of different experimental solutions initiated here, point to a modern route towards the search for a therapeutic solution for osteosarcoma.

The simple, structured presentation coupled with relevant information on the subject of micelle-based nanotherapeutic drug delivery make this monograph an essential handbook for pharmaceutical scientists involved in the field of nanomedicine, drug delivery, cancer therapy and any researchers assisting specialists in clinical oncology for the treatment of osteosarcoma.

Model Driven development (MDD) is a software and systems development model that involves the application of visual modeling principles and best practices.

The advancements in molecular marker discovery, genomics, transcriptomics and proteomics in recent years have enabled researchers to develop targeted therapies against cancers. Cancer research and management is multi-disciplinary and multimodal. In addition to conventional chemotherapy and radiotherapy, targeted immunotherapy has also provided considerable success in the clinic. There is also scientific evidence on the impact of alternative therapies on cancer patients.

Modern Cancer Therapies and Traditional Medicine: An Integrative Approach to Combat Cancers summarizes the general aspects of cancer therapy and management. Chapters cover cancer medicine in two broad sections, the book presents comprehensive information on a diverse range of cancer treatments. The first section covers conventional molecular oncology and therapy including targeted therapies, immunotherapies, cancer signaling pathways and the use of computational techniques. The second section focuses on traditional methods of treatment including the role of nutrition, traditional medicine, Yoga and Ayurveda in cancer prevention and management.

The book is an accessible update of the state of the art in cancer diagnostics and therapy for students and academicians at all levels.

Occupational disease is an important public health problem of the 21st century. Occupational disease still accounts for many preventable illnesses and injuries in the workplace. It is important to incorporate modern knowledge of disease epidemiology and cutting-edge diagnostic methods and treatment with the most recent developments in the management and prevention methods to better control work-related diseases and injuries. This book covers a selection of the common occupational diseases and injuries. It offers accurate, current information on the history, causes, diagnosis, management and prevention of several occupational diseases.

Key features:

- 14 chapters contributed by more than 30 experts in occupational and preventive medicine

- Comprehensive treatment of the history, causes, diagnosis, management and prevention of many important occupational diseases (including asbestosis, silicosis, work-related asthma, occupational cancer, mesothelioma, arsenic, and other diseases.).

- Each chapter highlights the latest research findings and cutting-edge technologies

- References for further reading

Modern Occupational Diseases: Diagnosis, Epidemiology, Management and Prevention serves as a useful guide for all readers interested in occupational diseases. The suggested readership includes trainees in occupational medicine, general practitioners, medical students, graduate students in public health programs, occupational health nurses, and professionals involved in occupational health and safety roles at public and private levels.

Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. It should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.

This book focuses on the physiology and molecular biology of the front and back regions of the eye. Specifically, the chapters of this book cover topics that explain currently less understood aspects of retinal health as well as the use of zebrafish models to understand the molecular pathogenesis of associated diseases. This includes retinitis pigmentosa, diabetic retinopathy ciliopathies in the eye, rhodopsin trafficking and associated disorders, and the biochemistry of cone defects. This book serves as a useful reference for scientists and graduate students seeking to understand protein trafficking mechanisms and metabolic control in retinal diseases.

This volume of Frontiers in Heart Failure comprehensively covers the gap between clinical management of heart failure and advanced molecular imaging techniques (SPECT, PET, MRI etc.). These techniques provide valuable evidence to cardiologists for the evaluation and follow-up of heart failure patients. It brings forth established research data regarding the pathophysiology, clinical presentations and therapy of heart failure, in a balance between clinical items and molecular imaging modalities. Readers will also find additional chapters on hybrid cardiovascular imaging techniques as well as guidelines on imaging artifacts and radiation protection. This volume is a useful resource for radiologists, cardiologists, cardiac care nurses and medical physicists.

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecular targets and rational drug design on this molecular basis should help in discovering early cancer biomarkers as well as novel therapeutic drugs.

This book describes various cancer topics on a molecular level and integrates information on the relationship between causes of cancer, cancer cell biology, metastasis, cancer prevention and drug design. This book should prove to be an extraordinary reference text for students, physicians and oncologists.

Today, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early-stage diagnosis.

Molecular Targets and Cancer presents information about cancer diagnosis and therapy in a simple way. It covers several aspects of the topic with updated information on par with medical board levels. The book features contributions from experts and includes an overview of cancer from basic biology and pathology, classifications, surveillance, prevention, diagnosis, types of cancer, treatment and prognosis.

The second part of this book discusses specialized topics in clinical oncology which include the pathophysiology of various types of cancer, cancer screening, different types of cancer surgery, cancer stem cell-targeted immunotherapy, nanotechnology for precision medicine applications in cancer and cancer surveillance.

This comprehensive guide is a valuable resource for oncologists, researchers, and all medical professionals who work in cancer care and research.

Molecular and Physiological Insights into Plant Stress Tolerance and Applications in Agriculture is an edited volume that presents research on plant stress responses at both molecular and physiological levels. Key Features: - Emphasizes the morphological and physiological reactions of plants and the underlying molecular mechanisms when faced with stress from environmental or pathogenic factors. - Explores microbial dynamics within the plant rhizosphere and the application of plant growth-promoting bacteria as biofertilizers and endophytes as biocontrol agents to enhance crop growth and productivity for sustainable agriculture. - Systematically summarizes molecular mechanisms in plant stress tolerance and discusses the current applications of biotechnology, nanotechnology, and precision breeding to obtain stress-tolerant crops, contributing to climate-smart agriculture and global food security. - Includes contributions and references from multidisciplinary experts in plant stress physiology, plant molecular biology, plant biotechnology, agronomy, agriculture, nanotechnology, and environmental science. The content of the book is aimed at addressing UN SDG goals 2, 12, and 15 to achieve zero hunger and responsible consumption and production, and to sustainable use of terrestrial ecosystems, respectively. This comprehensive resource is suitable for researchers, students, teachers, agriculturists, and readers in plant science, and allied disciplines.

Marine ecosystems offer several benefits to human communities. To make sustainable use of these benefits, it is necessary to elucidate and conserve marine ecology, and strive to maintain a sustainable natural resource management program. For this reason, understanding the diversity and behavior of both macro-ecosystems and micro-ecosystems are crucial.

Monitoring Artificial Materials and Microbes in Marine Ecosystems explores microbial roles and their interaction with artificial materials in marine environments. After starting with simple topics for beginners, chapters explore methods to detect microorganisms in marine ecosystems and interactions of marine organisms with artificial materials. The sequential progression into advanced topics makes it easier to understand how to solve the reduction in marine-ecosystem viability caused by adverse events. Readers are provided with useful information for rehabilitating marine environments to make them sustainable for communities.

Topics are covered in 3 parts:

Part 1 is an introductory guide to marine ecosystems and environmental monitoring assessment. Readers are introduced to coral reef ecosystems, algal blooms and the role of environmental monitoring services in maintaining and restoring the quality of marine environments. This is followed by examples of sustainable marine environment assessment.

Part 2 provides information about methods to detect microorganisms (viruses and bacteria) and evaluate marine environments. This includes sample enrichment methods, electrochemical analysis, and single-cell imaging techniques. The highly sensitive and specific techniques presented in the book, are applicable in a wide variety of situations.

Part 3 is dedicated to interactions between artificial metallic materials and microorganisms in marine environments. Chapters in this section share results from several experiments conducted to separate microorganisms and biofilms from such environments.

This book is intended primarily for marine ecologists, microbiologists, environmental engineers, and engineers associated with industrial projects. This book is also useful as a text for undergraduate and graduate-level courses in marine biology, ecology, and microbiology.

Morphea and Related Disorders is a comprehensive reference on morphea. The book covers the subject in 20 chapters. The book starts with a detailed introduction and history of the morphea and its various classifications systems. Next, the book progresses into epidemiology, predisposing factors and pathogenic mechanisms, followed by histopathology for morphea diagnosis and a detailed review of clinical presentations.

Subsequent chapters cover associated diseases and extracutaneous manifestations, medical investigations, treatment guidelines and special topics (Idiopathic atrophoderma of Pasini and Pierini, Linear atrophoderma of Moulin, Parry-Romberg syndrome, Lichen sclerosus, pediatric morphea and eosinophilic fasciitis).

Key features:

-he most detailed reference book on morphea

-Easy and simple language for readers

-Chapter synopsis at the beginning of each chapter

-Learning points at the end of the chapter

-More than 100 high resolution colored photographs

-Information boxes and tables to enhance readability.

-Covers basic knowledge on morphea, including pathogenesis, clinical presentations, and classification

-Includes guidelines for professionals

-Includes chapters on special topics for advanced readers

Morphea and Related Disorders is the definitive reference book for medical students, residents, instructors, and physicians.

Mucosal Vaccine Delivery Systems: The Future of Immunization – Part I presents a pioneering exploration into the realm of mucosal vaccination, covering innovative delivery platforms, immunological mechanisms, and their diverse applications in human and veterinary medicine. This comprehensive volume examines the regulatory, economic, and technological landscapes shaping mucosal vaccine development, highlighting their pivotal role in combating infectious diseases, chronic ailments, and advancing cancer immunotherapy.

Key Features:

- Detailed insights into nasal, oral, pulmonary, gastrointestinal, and urogenital vaccination.

- Analysis of mucosal vaccines in pediatric and elderly healthcare.

- Exploration of adjuvants, bioprocessing challenges, and commercialization trends.

- Contributions from leading researchers in the field.

Multiple drug resistance among bacteria has become a global issue with a considerable impact on the mortality associated with infectious diseases. This book is a detailed compilation of available knowledge on the surveillance and mechanisms of antibiotic resistance in various countries throughout the world. Readers will be updated on current information on the understanding of mechanisms involved in drug resistance and the geographical distribution of resistance determinant markers. This volume should be a useful guide for microbiologists and clinicians interested in designing antimicrobial therapies tailored for patients in specific geographical regions.

Multi-Objective Optimization in Theory and Practice is a traditional two-part approach to solving multi-objective optimization (MOO) problems namely the use of classical methods and evolutionary algorithms.

This first book is devoted to classical methods including the extended simplex method by Zeleny and preference-based techniques. This part covers three main topics through nine chapters. The first topic focuses on the design of such MOO problems, their complexities including nonlinearities and uncertainties, and optimality theory. The second topic introduces the founding solving methods including the extended simplex method to linear MOO problems and weighting objective methods. The third topic deals with particular structures of MOO problems, such as mixed-integer programming, hierarchical programming, fuzzy logic programming, and bimatrix games.

Multi-Objective Optimization in Theory and Practice is a user-friendly book with detailed, illustrated calculations, examples, test functions, and small-size applications in Mathematica® (among other mathematical packages) and from scholarly literature. It is an essential handbook for students and teachers involved in advanced optimization courses in engineering, information science, and mathematics degree programs.

The surge of multicore processors coming into the market and on users’ desktops has made parallel computing the focus of attention once again. This time, however, it is led by the industry, which ensures that multicore computing is here to stay. Nevertheless, there is still so much research work to be done in multicore hardware-software designs before consumer applications can leverage the benefits of this new paradigm. This ebook is being put forward as a platform for immediate collection of state-of-the-art technologies in both hardware and software designs for multicore computing. With the burgeoning prevalence of multicore processors in embedded systems, real-time systems, multimedia systems, bioinformatics systems, network systems, to list a few, this ebook attempts to cover the design and verification issues related to different application domains as a singular source of reference to the state-of-the-art techniques in multicore processor design and software programming that covers multiple application domains. This ebook will be of immense help to system and software engineers, including both experts and non-experts in parallel computing.

Multidisciplinary Interventions for People with Diverse Needs is a book written from an interdisciplinary perspective with the objective of helping readers to understand the problems faced by people with special needs.

Key Features:

- provides an updated theoretical and contextual foundation of medical issues

- provides information about the meaning, evaluation and intervention of the problems related to a variety of debilitating diseases and disability conditions (dementia, language disorders, diabetes, alterations of consciousness, celiac disease and disability in general)

- contains an accessible, well written, didactic text which is useful to both students and working professionals

The book equips the reader with information about different approaches to medical and social issues that arise when dealing with persons who are experiencing some degree of disability. For teachers and working professionals, the handbook serves as a guide for teaching, for the development of the structure of training courses, for the design of evaluation models and intervention of the topics addressed in the book.

The combination of information about the professional and human aspects of special needs education makes this book a useful reference for pedagogues, psychologists, students, teachers and professionals involved in social science, healthcare, and sports medicine, among other fields.

Affective computing is an emerging field situated at the intersection of artificial intelligence and behavioral science. Affective computing refers to studying and developing systems that recognize, interpret, process, and simulate human emotions. It has recently seen significant advances from exploratory studies to real-world applications.

Multimodal Affective Computing offers readers a concise overview of the state-of-the-art and emerging themes in affective computing, including a comprehensive review of the existing approaches in applied affective computing systems and social signal processing. It covers affective facial expression and recognition, affective body expression and recognition, affective speech processing, affective text, and dialogue processing, recognizing affect using physiological measures, computational models of emotion and theoretical foundations, and affective sound and music processing.

This book identifies future directions for the field and summarizes a set of guidelines for developing next-generation affective computing systems that are effective, safe, and human-centered.The book is an informative resource for academicians, professionals, researchers, and students at engineering and medical institutions working in the areas of applied affective computing, sentiment analysis, and emotion recognition.

This textbook provides a quick and easy understanding of multistage interconnection networks (MINs) for engineers. The book contents focus on the design, performance metrics, and evaluation of these networks which are crucial in modern computer architecture. The contents equip engineering students, apprentices and professionals with in-depth knowledge and analysis of MINS, enabling them to build complex computer architectures for efficient data communications and cost effective solutions for circuit design. The book starts with an introduction to MINS and subsequently progresses to the evaluation of a range of MINS (SEN, Gamma-Minus, FTSN, FTGN, SEGIN). Key highlights of the book include: & Easy to understand notes on design, reliability and fault tolerance & Covers a wide range of MIN types with notes on design variants & Supplementary information aiding comprehension of the main content. & A curated list of references for further exploration and deeper understanding.

Fungi are extremely versatile microorganisms as a biotechnology tool having the advantage of being relatively easy to grow, thus making them suitable for large scale production. Fungi have been successfully employed for biotransformations ranging from food manufacturing to drug design. Mycofactories comprise a substantial share of significant current research in the area of fungal biotechnology, and constitutes an effort to compile high level research in this domain. Topics include applications of fungi as a main source for the production of enzymes, manufacture of food derivatives, pigments and additives, and applications in bioremediation.

This volume presents an illuminating analysis of the ways in which normalization processes and practices operate in a welfare state in an age of neoliberalism. This informative book problematizes the meaning of the phrase ‘normalization processes and practices’, that for an Anglophone audience may smack of functionalism. The historical context of the deliberate adoption of normalization processes and practices in Sweden in the post-World War II era was, in the first instance, an expression of the inclusivity designed to decrease inequalities and to achieve social justice. However all the contributors to this volume, show very clearly how notions of normalcy, of normalization, in a neoliberal time operate not only to create an integrating and equalizing context but also, and much more critically, to exclude certain groups of people, and produce a structural inequality that in recent years has been discussed under the term of ‘utanförskap’ or outsiderhood.

Critiquing these interventions, the contributors to this volume show how diverse groups of people - immigrants, families considered 'at risk' by social services, pregnant women, young girls - are variously the objects of context-specific normalization processes and practices that make any resistance to such interventions difficult, if not impossible. What people 'normally do', cloaks that 'normal doing' with a fog of invisibilization that suffocates any form of protest. Normalization thus takes on specific forms of repression in particular circumstances, for instance through the ethnocentric imposition of norms of behaviour on migrants where that ethnocentricity is neither made evident nor acknowledged. This system of normalization also operates in schools, resulting in the reproduction of inequalities and discrimination from an early age. In such normalization processes 'the normal' or 'the usual' becomes a means for reinterpreting structural inequalities in terms of individual choice, and for displacing the responsibilities for change onto those positioned as outsiders. The individual chapters highlight how the operations of normalizing processes work to obscure their functioning, thus making any critique of both the underlying assumptions and their operationalization almost impossible.

This textbook provides an overview of next-generation Field-Effect Transistor (FET) technologies at the intersection of nanoelectronics, device miniaturization, and advanced applications. With a special emphasis on the evolution of semiconductor engineering, the book examines the shift from conventional CMOS to emerging FET architectures aimed at extending Moore ' s Law.

Across 18 chapters, the book explores Tunnel FETs (TFETs), carbon-based FETs, and 2D-material transistors, with discussions on performance, scalability, and reliability. It features detailed analyses of advanced device structures such as HJ-DGV-TFETs, dual-pocket step-channel TFETs, and AlGaN/GaN HEMTs, as well as their roles in memory, photonics, and biomedical systems. The use of nanomaterials in biosensor integration and digital circuit design is also a key theme.

Key features:

-Traces technological transitions from CMOS to novel FETs

-Examines nanoengineered device architectures and materials

-Investigates applications in optoelectronics, memory, and biosensing

-Analyzes simulation approaches for performance optimization

-Highlights interdisciplinary innovations across electronics and healthcare.

Nanobiomedicine: Fundamentals and Implementation in Theranostic Applications explores how the fusion of nanotechnology, biotechnology, and medicine is transforming modern healthcare. Addressing the limitations of conventional diagnostics and therapies, the book explains how nanoparticles enable targeted drug delivery, improved imaging, and combined diagnostic-therapeutic (theranostic) applications, especially in cancer care.

Chapters cover the fundamentals of nanomaterials, their use in photodynamic therapy, immunotherapy, and gene therapy, and their role in protecting and transporting drugs, DNA, and RNA. The book also highlights the growing impact of Artificial Intelligence, with applications in Alzheimer’s detection, AI-driven drug discovery, and ML/DL-based nanomedicine design.

Key Features

Explain nanoparticle-based drug and gene delivery for targeted treatment

Demonstrate theranostic applications integrating diagnosis and therapy

Highlight nanomedicine in cancer treatment to reduce damage to healthy cells

Explore AI-assisted diagnostics and drug discovery for personalised healthcare

Present emerging nanomaterial strategies for imaging, formulation, and acute therapy

This Reference eBook deals with an existing classification of a nanosized structure and an analysis of its properties. It summarizes an information about how a grain size affects physical, mechanical, thermal, and other properties of a nanostructured material. A basic method, which is employed for a fabrication of an isolated nanoparticle, an ultradisperse powder, a compact nanocystalline, nanoporous, and amorphous material, a fullerene, a nanotube, and a nanostuctured coating, is considered. Investigation methods, which are applied to study the nanostructured material, are briefly described. A modern understanding of a formation of the nanostructured and nanocomposite coating, which are fabricated using a ion-plasma deposition method, is reposted. A potential application of the nanostructured material and coating in a field of engineering is demonstrated.

Readership: Graduate, Postgraduate, Ph.D. Students, Researchers and Industry Professionals.

The eBook contains 9 Chapters, 87 Figures, 14 Tables, 411 References-totally, 155 Pages. It was approved by two Scientific Boards from National Kharkov University and Sumy State University.

A main content of this eBook is a basis for lectures presented for students at Sumy State University (the Physical-Technical Faculty), Kharkov National University (the Physical Faculty), Omsk State University (the Physical Faculty, the Department of Material Science), East-Kazakhstan State Technical University (Ust-Kamenogorsk, Kazakhstan), and Moscow State University (the Physical Faculty, Moscow, Russia).

A source of this eBook is original papers of leading world-known scientists, who ware involved in a field of new nano composite material fabrication, nanotechnologies, and researches. This version had not been published elsewhere. It is interesting for a wide circle of specialists, Masters, aspirants, scientific researchers, and a technical staff of Higher Education System, Research Institutes and Laboratories. It covers recent data since 2008 to 2010 year.