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The Role of Anti-MDA5 Antibodies in Rapidly Progressive Interstitial Lung Disease: A Case Report and Literature Review
Available online: 13 May 2025More LessIntroduction Anti-melanoma Differentiation-associated Gene 5 (aMDA5) antibody-associated Rapidly Progressive Interstitial Lung Disease (RP-ILD) is a rare and potentially fatal condition. Methods This case report describes a 78-year-old male who presented with a 10-day history of fever, cough, and asthenia. Results Despite initial treatment for suspected atypical pneumonia, the clinical condition of the patient rapidly deteriorated Read More
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A Prospective Study on the Role of Strain Echocardiography in Detecting Early Radiation-induced Cardiotoxicity in Left-sided Breast Cancer Patients
Available online: 08 May 2025More LessIntroduction Radiotherapy for breast cancer has a clear benefit for long-term survival and local control rate. However, it can negatively impact a patient’s quality of life by affecting healthy surrounding normal tissues, including the heart and lungs. This study aimed to clarify the contribution of echocardiography with Global Longitudinal Strain (GLS) to early radiation-induced cardiotoxicity detection. Methods A prospective study Read More
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The Quality of Methodological Reporting of Randomised Controlled Trial (RCT) Articles Published in Iranian and Top Nursing and Midwifery Journals Indexed in the Scopus Database using the CONSORT Checklist: A Cross-sectional Study
Authors: Razieh Bagherzadeh, Siavash Asadzadeh Jahanabad and Leila DehghaniAvailable online: 07 May 2025More LessIntroduction The quality of methodological reporting in randomized controlled trials (RCTs) is crucial for guiding healthcare decisions. This study compares the methodological reporting of RCT articles published in Iranian nursing and midwifery journals indexed in Scopus with those published in international nursing and midwifery journals also indexed in Scopus. Methods This comparative cross-sectional study reviewed RCT art Read More
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Wound Healing Complications after Neoadjuvant Radiotherapy Combined with Targeted Therapies in Soft Tissue Sarcoma Patients
Authors: Nikolaos S Georgopoulos, Maria Tolia, Annita Boulouta, Anastasios Kyriazoglou, Vasileios Patriarcheas, Evangelos Dimakakos, Dimitrios Schizas, Davide Mauri, Nikolaos Tsoukalas, Nikolaos Charalampakis, Ramon Andrade De Mello, Chrysostomos Antoniadis, Eelco de Bree, Dimosthenis Michelakis, Konstantinos Tsapakidis, Michalis Mazonakis, Pantelis Kountourakis, Ioanna Nixon, Dimitrios Mavroudis and Areti GkantaifiAvailable online: 07 May 2025More LessIntroduction/ObjectiveSignificant advancements have been achieved with the use of targeted molecular therapies for the treatment of Soft Tissue Sarcomas (STS). However, data remain scarce about the potential benefits and toxicity of this therapeutic option. In this narrative review, we aim to better clarify the potential wound healing complications in STS patients undergoing neoadjuvant (NA) radiotherapy (RT) combined wit Read More
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Transformative Paths: Preclinical Drug Formulation and Delivery
Approaches in DevelopmentAuthors: Deepshi Arora, Anjali Sharma, Prabhjot Kaur, Vishnu Mittal, Moin, Yugam Taneja and Devkant SharmaAvailable online: 25 April 2025More LessThis comprehensive review explores the multifaceted landscape of preclinical drug development, encompassing crucial stages, regulatory intricacies, Investigational New Drug (IND) submissions, and innovative formulation strategies. Delving into preclinical studies, the review underscores the importance of pharmacokinetics, pharmacodynamics, and safety assessments in animal models. Regulatory requireme Read More
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Sexual Dysfunctions in Chronic Liver Diseases: A Narrative Review on Prevalence and Putative Pathophysiologic Mechanisms
Available online: 24 April 2025More LessIntroduction/Objectives Chronic liver diseases have been reported to be associated with altered sexual function. The existing gap in understanding the pathophysiological mechanisms linking sexual disorders and chronic liver diseases may explain the lack of attention given to sexual health in this cohort of patients. We, therefore, aimed at reviewing the available evidence linking chronic liver diseases and sexual dysfunction in Read More
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Cybersecurity and Compliance in Clinical Trials: The Role of Artificial Intelligence in Secure Healthcare Management
Authors: Virendra S. Gomase, Arjun P. Ghatule, Rupali Sharma and Satish SardanaAvailable online: 24 April 2025More LessRapid healthcare digitization has created both previously unheard-of potential and serious data management weaknesses, especially in clinical trials. Artificial Intelligence (AI) offers innovative approaches to enhancing cybersecurity and ensuring legal compliance in healthcare systems. Protecting private information from internet threats is more crucial than ever because clinical trials are increasingly reliant on patient d Read More
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Immune Checkpoint Inhibitors Impact Fertility: A Review
Authors: Iram Shabir and Christina FosterAvailable online: 04 February 2025More LessImmune checkpoint inhibitor therapy has become the established method of treatment for various types of cancers, consequently introducing a spectrum of side effects referred to as immune-mediated adverse events, affecting almost every organ, including the reproductive system. Moreover, very little clinical data is available that suggests the detrimental effect of immune checkpoint inhibitor therapy on fertility, sex Read More
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The Effect of Foot Reflexology on the Sexual Function of Lactating Women: A Randomized Clinical Trial
Authors: Zahra Ghanbari, Mahboubeh Valiani and Shahnaz KohanAvailable online: 04 February 2025More LessBackground Sexual health is an essential part of women's lives at different ages. Pregnancy, childbirth, and breastfeeding can affect women's sexual function by inducing biological, psychological, and social changes. Due to the prevalence of sexual dysfunction in lactating women and the effects of reflexology therapies on it, this study was conducted to investigate the effect of foot reflexology on the sexual function of lact Read More
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From Paper to Digital: Evaluating Electronic Medical Records and their Compliance with EMA Guidelines in European Clinical Trials
Available online: 27 January 2025More LessBackground Over the past decade, there has been a significant shift from paper-based to digital medical record management, driven largely by advances in digital technology. This transition has led to widespread adoption of Electronic Medical Records (EMRs), with the expectation that paper documentation will soon be fully replaced. In response, the European Medicines Agency's “Guideline on Computerised Systems in Clinical Read More
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New Research on Biomarkers in Alzheimer’s Continuum
Authors: Immacolata Vecchio and Carmela ColicaAvailable online: 24 January 2025More LessAlzheimer’s disease (AD) is a multifactorial pathology, responsible for neurodegenerative disorders which in more than 60% of patients evolve into dementia. Comprehension of the molecular mechanisms underlying the pathology and the development of reliable diagnostic methods have made new and more effective therapies possible. In recent years, in addition to the classic anticholinesterases (AChEs), which can control the Read More
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Blockchain as a Prime Guardian: Securing Clinical Trial Data Integrity
Authors: Nikhil Sethi, Charul Rathore and Dilpreet SinghAvailable online: 23 January 2025More LessThe present study focuses on the possible use of the emerging technology of blockchain in ensuring data management security in clinical trials. With the determination of the chief researchers and clinical investigations becoming more and more complex and international, achieving data quality and integrity, transparency, and legal compliance becomes imperative. By offering a distributed and immutable time-stamped le Read More
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Navigating Dry Eye Research: A Comprehensive Review of Etiology, Clinical Trials, Patents, and Recent Advancements
Authors: Vindhya Pal and Sushma VermaAvailable online: 09 October 2024More LessBackground Millions of people worldwide suffer from dry eye disease. Dry eye, a multifunctional condition of the ocular surface, typically occurs in conjunction with an unbalanced tear film. With increasing age, the dry eye problem becomes worse. Aqueous-deficit dry eye and evaporative dry eye are the two traditional classifications for dry eye. Various examination tools are used to diagnose dry eye. Clinical trials are conduct Read More
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COVID-19 Vaccinations: Summary Guidance for Cancer Patients in 28 Languages: Breaking Barriers to Cancer Patient Information
Authors: Davide Mauri, Konstantinos Kamposioras, Lampriani Tsali, Mario Dambrosio, Berardino De Bari, Nadia Hindi, Carl Salembier, Joanna Nixon, Tzachanis Dimitrios, Flippo Alongi, Hassan Hameed, Antonios Valachis, Konstantinos Papadimitriou, Stefanie Corradini, Lazar Popovic, Jindrich Kopecky, Andres Rodriguez, Katarina Antunac, Junlin Yi, Jozsef Lovey, Primoz Strojan, Haytham Saraireh, Ranveig Røtterud, Marzanna Chojnacka, Santa C. Olalla, Natalia Chilingirova, Ramon Andrade De Mello, Giovanna Araujo Amaral, Farsid Arbabi, Radu Vidra, Erjeta Rapushi, Dan Takeuchi, Chirstos Christopoulos, Irina Ivanova, Igor Djan, Branka Petricevic, Francesco Cellini, Iglika Mihaylova, Natalija Dedic Plavetic, Cvetka Grašič Kuhar, Elena Takeuchi, Pantelis Kountourakis, Panagiotis Ntellas, Ioanna Gazouli, Stefania Gkoura, Salih Yuce, Özlem ER, Chait Yasmina, Gireesh Kumaran, Orges Spahiu, Aasim Yusuf, Paulina Gono, Kathi Apostolidis and Maria Tolia
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Deep Neck Infections: Decisional Algorithm for Patients with Multiple Spaces Involvement
Authors: Filippo Ricciardiello, Salvatore Mazzone, Pasquale Viola, Gianluca Guggino, Giuseppe Longo, Alberto Napolitano, Giuseppe Russo, Giulio Sequino, Flavia Oliva, Pasquale Salomone, Marco Perrella, Giovanni M. Romano, Pietro Cinaglia, Teresa Abate, Maurizio Gargiulo, Davide Pisani and Giuseppe Chiarella
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